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(2002) Rivastigmine for the treat-ment of dementia and visual hallucinations associated withParkinson’s disease: a case series. Melatonin isalso powerful antioxidant as it can directly scavenge ROS and RNS (such as superoxide,hydroxyl radical and nitric oxide), it stimulates the action of other antioxidants, increases theefficiency of mitochondrial oxidative phosphorylation and reduces electron leakage (thuslowering generation of superoxide) and it can protect nuclear and mitochondrial DNA (Reiteret al., 2003).
When adminis-tered orally it undergoes little first pass meta-bolism: bioavailability is high, interindividualdifferences are minimal and it is longer acting(t? 4–6 hr).
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